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DrLOUIE Cleansing Duo

What Sets Them Apart: Dark Spot Serum vs. Vitamin C Serum

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Time to read 3 min

When building a skincare routine, it can be difficult to choose the right product for your skin's specific needs. And we've received so many questions about the differences between these two formulas that target hyperpigment and dull skin tone —Dark Spot Serum and Vitamin C Serum.


Each serves a distinct purpose, with unique ingredients, application methods, and target concerns. 


Here’s how they differ, so you can choose the one that fits best.

1. At-a-Glance Comparison

flower with pollen floating in air
Feature Dark Spot Serum Vitamin C Serum
Primary Vitamin C type Ascorbyle Glucoside (AA2G) L-Ascorbic Acid (20%)
Primary Ingredient Lactic Acid (10%) L-Ascorbic Acid (20%)
Key Benefits
  • Fades pigmentation
  • Gently exfoliates
  • Overall brightening
  • Strong antioxidant protection
  • Boosting collagen production
Use Case Spot-correcting (topical) Daily power boost of antioxidant and radiance (full-face)
When to use Night time (topical) Morning under All-in-One Essence or other moisturizer, and sunscreen

This table shows an overall picture of the differences between Dark Spot Serum and Vitamin C Serum.

2. Full Ingredient Breakdown

Dark Spot Serum

Full INCI List

Aqua (Water), Lactic Acid, Arginine, Glycerin, Ascorbyl Glucoside, Phyllanthus Emblica Fruit Extract, Caprylyl Glycol, Mannitol, Waltheria Indica Extract, Sodium Gluconate, Sodium Citrate, Allantoin, Aloe Leaf Juice, Dextrin, Citric Acid, Ferulic Acid

Notable Actives

Lactic Acid, Ascorbyl Glucoside, Emblica™, Ferulic Acid, Allantoin

  • 10% Lactic Acid - Exfoliates surface cells, fades dark spots, and improves texture
  • Ascorbyl Glucoside (AA2G) - Stable Vitamin C derivative that brightens and evens tone over time
  • EmblicaTM - Natural patented antioxidant that inhibits melanin formation and reduces pigmentation

Vitamin C Serum

Full INCI List

Aqua (Water), Ascorbic Acid, Glycerin, Panthenol, Allantoin, Hyaluronic Acid, Arginine, Caprylyl Glycol, Phyllanthus Emblica Fruit Extract, Aloe Barbadensis Leaf Juice

Notable Actives

20% L-ascorbic acid, Allantoin, Panthenol (Dexpanthenol), EmblicaTM

  • 20% L-Ascorbic Acid - High potency, pure Vitamin C with most clinical studies behind. Boosts collagen, brightens skin, and fights environmental damage
  • Allantoin - Calms irritation and support skin recovery
  • 3% Panthenol (Dexpanthenol) - Hydrates, enhances skin elasticity and supports skin barrier
  • 1% EmblicaTM - Natural patented antioxidant that inhibits melanin formation and reduces pigmentation

3. Vitamin C Sources: How They Differ

flower with pollen floating in air

Each product uses a distinct form of vitamin C, each with unique origins, mechanisms, strengths, and limitations:


  • Ascorbyl Glucoside (AA2G) — Found in Dark Spot Serum

    • Origin: A stable vitamin C derivative created by attaching glucose to ascorbic acid

    • Benefits: More stable than L-ascorbic acid, penetrates skin where it is enzymatically converted to active vitamin C. Gentler and well-suited for sensitive skin or localized use

    • Weaknesses: Slower to act; requires enzymatic activation so results are gradual

    • Clinical Support: Shown in peer-reviewed studies to reduce melanin and improve brightness over time without irritation ( Wang et al., 2022 )


  • L-Ascorbic Acid — Found in Vitamin C Serum

    • Origin: The pure, active form of vitamin C found naturally in fruits

    • Benefits: High antioxidant capacity, boosts collagen synthesis, provides fast brightening and environmental protection

    • Weaknesses: Unstable in light and air, may oxidize; best used quickly in low-pH, airtight packaging. Can cause tingling or irritation in sensitive skin

    • Clinical Support: Considered the gold standard in dermatology for skin lightening and anti-aging ( Pinnell et al., 2001 )


  • Emblica™ (Phyllanthus Emblica Extract) — Found at 1% in Vitamin C Serum)

    • Origin: Derived from Indian Gooseberry, a potent botanical source of natural polyphenols and vitamin C–like compounds

    • Benefits: Extremely stable, suitable for sensitive skin, provides long-lasting antioxidant protection, inhibits melanin formation without irritation

    • Weaknesses: Slower to produce visible brightening effects compared to L-ascorbic acid; often used as a supportive antioxidant

    • Clinical Support: Demonstrated to inhibit tyrosinase activity and reduce UV-induced pigmentation ( Al-Niaimi & Chiang, 2017 )

4. Application Differences

Product Application Routine Frequency
Dark Spot Serum Apply to affected areas (topicallyi) after cleansing and before moisturizing. Best at night Every night
Vitamin C Serum Apply on clean skin in the morning. Followed by All-in-One Essence or moisturizer and SPF. Every morning

5. Recommended Product for Different Skin Concern

Skin Concern Recommended Product Why
Dark spots, severe hyperpigmentation Dark Spot Serum Combines gentle exfoliation and cell turnover (10% Lactic acid) with stable Vitamin C for targeted brightening
Overall dull skin tone, early signs of aging, less severe hyperpigmentation Vitamin C Serum Pure, potent form of vitamin C (20% L-ascorbic acid) to brighten, boost collagen production, and double boost of antioxidant protection
flower with pollen floating in air
flower with pollen floating in air

6. Still Not Sure Which to Choose?

Antioxidant Boost/Dull Skin:

If you need more antioxidant boost or feel that your skin is dehydrated, looking dull with visible signs of aging, then add Vitamin C Serum in the morning.


Hyperpigment Targeted Care

If your concerns are dark spots AND overall dull skin tone, add Dark Spot Serum at night for targeted concerns and Vitamin C Serum in the morning. Layered smartly, they work even better together.


And you can always start a live chat if you'd like a product recommendation. One of our friendly HUMAN representatives, who know our products and their workings inside out, can help you!